Click Activated Protodrugs Against Cancer (CAPAC™)

Our revolutionary platform precisely activates powerful therapies in the tumor

About the CAPAC™ Platform

The Click Activated Protodrugs Against Cancer (CAPAC™) Platform is a new therapeutic modality based on click chemistry, which utilizes the biocompatible chemical reaction between an attenuated trans-cyclooctene-modified protodrug and a tetrazine-modified biopolymer. The biopolymer is injected in the desired tumor, which then captures and activates an infused protodrug precisely at the tumor site. The CAPAC Platform is designed to increase anti-tumor efficacy while minimizing systemic toxicity. The platform is agnostic to tumor characteristics that can vary from patient to patient, such as biomarker expression and enzymatic activity. Shasqi’s CAPAC platform is highly modular and can be applied to a wide variety of cancer therapeutics.