Targeting cancer with Click Chemistry

Less than 1% of administered drugs make it to their desired location in the body.

Next generation tumor-targeting

Our proprietary Click Activated Protodrugs Against Cancer (CAPAC®) platform is a pre-targeting approach, capturing payloads at the tumor via in-vivo click chemistry, a  2022 Nobel Prize-winning technology.

We are the first company to use click chemistry in patients.

CAPAC is modular

CAPAC separates the binder from the payload and reunites them at the tumor.
Clickable binder
Binds selectively to the tumor
Clickable payload
Either a radioisotope or  cancer drug that is inert until it clicks with the binder at the tumor

Activation

When the systemically administered clickable payload reaches the clickable binder at the tumor, a click chemistry reaction takes place. For radioisotopes, this locks the radioisotope at the tumor; for chemotherapy this activates the payload.

Changing what's possible

We separate tumor targeting from the payload, and rely on chemistry, not biology, for activation. This leads to maximum active payload at the tumor and lower systemic toxicity than has been previously possible.

CAPAC is designed to expand the scope of potential targets and widen the therapeutic window of antibody drug conjugates (ADCs) and targeted radiopharm approaches. CAPAC has been validated in the clinic and we are rapidly advancing novel therapies for patients with limited effective treatment options.
Our platform

Latest News

January 13 - 16
press
Shasqi to present at 2025 JPM Healthcare Conference

San Francisco, CA January 8th, 2025 (PR NEWSWIRE) -- Shasqi, Inc. (“Shasqi”) a biotech company whose mission is to make cancer drugs more effective with click chemistry, today announced that Founder and Chief Executive Officer José M. Mejía Oneto, MD, PhD, will present at the 43rd Annual J.P. Morgan Healthcare Conference on Thursday January 16th at 11:00am Pacific Time / 2:00pm Eastern time in conference hall Elizabethan C.  

Dr. Mejía Oneto will be sharing emerging data from Shasqi’s novel Click Activated Protodrugs Against Cancer (CAPAC®) technology, a pre-targeting approach that separates the binder from the payload and reunites them at the tumor using in vivo click chemistry.  

"We are honored to present at this year’s J.P. Morgan Healthcare Conference” said Shasqi Founder and CEO, José Mejía Oneto, MD, PhD. “Using CAPAC, we are able to preferentially activate powerful cancer drugs at the tumor in ways that are impossible with ADCs. Our lead asset, a CEACAM5 binder with an MMAE payload, is showing incredible preclinical efficacy and we are excited to debut these data at JPM.”

About Shasqi and CAPAC®

Shasqi’s Click Activated Protodrugs Against Cancer (CAPAC ®) technology is a pre-targeting approach using in vivo click chemistry to enable preferential drug exposure in tumors versus normal tissues. The approach comprises: 1) a clickable binder, and 2) a clickable payload (‘protodrug’). When reunited at the tumor using click chemistry, these components lead to maximal active therapeutic payload. CAPAC is designed to expand the scope of potential targets and widen the therapeutic window of antibody drug conjugates (ADCs) and targeted radiopharmaceuticals approaches.  

Together we can transform cancer treatment

Ready to help us develop the future of cancer therapies?
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