2001
The term click chemistry is coined by Kolb, Finn and Sharpless: a highly selective set of chemical reactions that can occur even in a glass of water.
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Shasqi is a privately held, clinical stage biotechnology company whose mission is to enable patients to beat cancer without poisoning their body. Shasqi leverages its proprietary CAPAC™ Platform to develop precision activated oncology therapeutics.
Our revolutionary platform precisely activates powerful therapies in the tumor. Designed to improve efficacy while decreasing systemic toxicity, Shasqi’s CAPAC Platform is highly modular and can be applied to a broad range of drugs that are otherwise limited by toxicity, enabling the exploration of therapeutic biology in ways that were not previously possible.
The term click chemistry is coined by Kolb, Finn and Sharpless: a highly selective set of chemical reactions that can occur even in a glass of water.
Read MorePrescher, Dube, and Bertozzi report the use of click chemistry to modify cells in living animals.
Read MoreBlackman, Royzen, and Fox pioneer the tetrazine ligation, an exceptionally powerful and efficient type of click chemistry.
Read MoreShasqi’s founder presents the foundational concepts of the Click Activated Protodrugs Against Cancer (CAPAC) Platform and shows the concept works in mice using the tetrazine ligation.
Read MoreShasqi shows that a cancer drug improved with the CAPAC Platform can lead to fewer side effects and better efficacy against tumors in mice.
Read MoreFDA and Australian Ethics Committee provide permission to proceed with first in human clinical study.
Read MoreShasqi presents anti-tumor responses for SQ3370, CAPAC’s lead candidate, in preclinical cancer model. (AACR)
Read MoreThe first patient dosed with Shasqi's SQ3370. First ever use of click chemistry in humans.
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