We believe you can beat cancer
without poisoning your body.

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About Shasqi

Shasqi is a privately held, clinical stage biotechnology company whose mission is to enable patients to beat cancer without poisoning their body. Shasqi leverages its proprietary CAPAC™ Platform to develop precision activated oncology therapeutics.

Click Activated Protodrugs Against Cancer (CAPAC™)

Our revolutionary platform precisely activates powerful therapies in the tumor. Designed to improve efficacy while decreasing systemic toxicity, Shasqi’s CAPAC Platform is highly modular and can be applied to a broad range of drugs that are otherwise limited by toxicity, enabling the exploration of therapeutic biology in ways that were not previously possible.

Overview of the CAPAC platform development

  • 2001

    The term click chemistry is coined by Kolb, Finn and Sharpless: a highly selective set of chemical reactions that can occur even in a glass of water.

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  • 2004

    Prescher, Dube, and Bertozzi report the use of click chemistry to modify cells in living animals.

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  • 2008

    Blackman, Royzen, and Fox pioneer the tetrazine ligation, an exceptionally powerful and efficient type of click chemistry.

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  • 2014

    Shasqi’s founder presents the foundational concepts of the Click Activated Protodrugs Against Cancer (CAPAC) Platform and shows the concept works in mice using the tetrazine ligation.

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  • 2016

    Shasqi shows that a cancer drug improved with the CAPAC Platform can lead to fewer side effects and better efficacy against tumors in mice.

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  • 2019

    Shasqi Announces Series A Financing.

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  • 2020

    FDA and Australian Ethics Committee provide permission to proceed with first in human clinical study.

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  • 2020

    Shasqi presents anti-tumor responses for SQ3370, CAPAC’s lead candidate, in preclinical cancer model. (AACR)

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  • 2020

    The first patient dosed with Shasqi's SQ3370. First ever use of click chemistry in humans.

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