Shasqi Awarded Prestigious Direct-to-Phase-2 Small Business Innovation Research Grant by National Cancer Institute

- $2 million grant will fund immune biomarker analysis in Phase 1 clinical study of SQ3370 as well as manufacturing process development

- SQ3370 is a click-activated protodrug therapy currently in a Phase 1 clinical study in advanced sarcomas and other solid tumors

SAN FRANCISCO, April 27, 2021, Shasqi, a clinical-stage biotechnology company developing precision activated oncology therapeutics with its proprietary Click Activated Protodrugs Against Cancer (CAPAC™) Platform, announced today that it has been awarded a $2 million Direct-to-Phase-2 Small Business Innovation Research (SBIR) grant from the National Cancer Institute (NCI). These non-dilutive funds will support immune biomarker analysis of patient samples from Shasqi’s Phase 1 clinical trial of lead candidate SQ3370 as well as manufacturing process development.

“We are thrilled the NCI sees the potential of SQ3370 as a novel therapy that could meaningfully impact outcomes for patients with solid tumors,” said José M. Mejía Oneto, M.D., Ph.D., Founder and CEO of Shasqi. “Our goal at Shasqi is to improve the safety and efficacy of novel and existing standard of care cancer drugs by directly activating them at the tumor. Our approach is designed to improve the therapeutic window of a drug by maximizing the exposure of the drug to the tumor.”

Wayne Saville, M.D.,  commented, “We appreciate the NCI’s support to evaluate the immune signatures in patient samples from our ongoing Phase 1 trial of SQ3370. This information will provide mechanistic insight about the interplay between SQ3370 and changes to local and systemic immune responses observed in our preclinical tumor studies. In addition, funds from this grant will also allow us to fine-tune our current manufacturing process as we continue to advance SQ3370 through clinical studies.”

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